The 1800 census for Georgia, Kentucky, New Jersey, Tennessee and Virginia were lost as well as the Indiana, Mississippi and Northwest territories (only Washington County records from the Northwest territory survived).
There are long running arguments about the invention of the cotton gin, which revolutionized the tedious process of cleaning fiber from seeds of cotton. What isn't up for debate is that Eli Whitney patented the cotton gin in 1794 leading to widespread use as well as piracy of the machine. Whitney produced little profit after years of court battles and licensing infringement over the invention.
With the invention of the cotton gin (short for engine), cotton grew into the most important harvest in the US during the turn of the 19th century. Production of cotton grew astronomically in the coming decades, the system profiting even further by way of slave labor. By 1860, one third of the Southern population, or 4 million people, in the US would be enslaved.